Abstract: Objective：To analyze the distribution characteristics and drug resistance of pathogens causing bloodstream infections in
the Daye area, and to provide a reference basis for clinical diagnosis, treatment, and empirical antimicrobial therapy. Methods: A retro⁃
spective analysis was conducted on the clinical data of adult patients with bloodstream infections in Daye People's Hospital from Sep⁃
tember 2022 to September 2024. The distribution and drug resistance of pathogens were statistically analyzed. Results: The top five
pathogens with the highest detection rates were Escherichia coli (accounting for 32.54%), Staphylococcus hominis (accounting for
12.70%), Klebsiella pneumoniae (accounting for 9.26%), Staphylococcus aureus (accounting for 6.08%), and Staphylococcus epidermidis
(accounting for 5.03%) in sequence. Pathogen distribution was significantly associated with sex, type of underlying disease, and some
clinical departments (P < 0.05). The detection rates of methicillin-resistant coagulase-negative staphylococci and methicillin-resistant
Staphylococcus aureus were 65.77% and 30.43%, respectively. Both strains were completely susceptible to vancomycin and linezolid.
Escherichia coli isolates were completely susceptible to carbapenems and tigecycline, with a high resistance rate of 71.43% to
sulfamethoxazole-trimethoprim. The detection rate of extended-spectrum β-lactamase-producing E. coli was 44.72%. Klebsiella pneu⁃
moniae isolates showed complete susceptiblility to minocycline. Conclusion: Staphylococcus species and E. coli are the primary patho⁃
gens causing bloodstream infections in the Daye area. Clinically, the pathogen detection strategy and empirical anti-infection regimens
should be optimized in combination with the distribution and drug resistance characteristics of pathogens in the local area to reduce the
incidence of infection and the risk of multi-drug resistant bacteria.

Key words: blood culture, bloodstream infection, drug resistance, multi-drug resistance